RSS Science News

  • Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation January 17, 2019
    Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical mouse models of cytomegalovirus reactivation after transplantation and found that humoral immunity is essential for preventing viral recrudescence. Preexisting antiviral antibodies decreased after transplant in the presence of graft-versus-host disease and were not replaced, owing to poor reconstitution […]
    Martins, J. P., Andoniou, C. E., Fleming, P., Kuns, R. D., Schuster, I. S., Voigt, V., Daly, S., Varelias, A., Tey, S.-K., Degli-Esposti, M. A., Hill, G. R.
  • Earth and Moon impact flux increased at the end of the Paleozoic January 17, 2019
    The terrestrial impact crater record is commonly assumed to be biased, with erosion thought to eliminate older craters, even on stable terrains. Given that the same projectile population strikes Earth and the Moon, terrestrial selection effects can be quantified by using a method to date lunar craters with diameters greater than 10 kilometers and younger […]
    Mazrouei, S., Ghent, R. R., Bottke, W. F., Parker, A. H., Gernon, T. M.
  • Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis January 17, 2019
    The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong Gram-positive and Gram-negative antibiotic character. Synthetic strategies toward these complex polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet–Spengler reaction, that mimics their biosynthetic pathways. Herein, we […]
    Welin, E. R., Ngamnithiporn, A., Klatte, M., Lapointe, G., Pototschnig, G. M., McDermott, M. S. J., Conklin, D., Gilmore, C. D., Tadross, P. M., Haley, C. K., Negoro, K., Glibstrup, E., Grünanger, C. U., Allan, K. M., Virgil, S. C., Slamon, D. J., Stoltz, B. M.
  • Pathogens at the limits January 17, 2019
    Sugden, A. M.
  • Precision CRISPR editing January 17, 2019
    Mao, S.
  • The cerebellum and reward-driven behavior January 17, 2019
    Stern, P.
  • Reversing chromatin dynamics for development January 17, 2019
    Purnell, B. A.
  • Flotilla launches large survey of Antarctic krill January 17, 2019
    Stokstad, E.
  • The bones of Bears Ears January 17, 2019
    Reese, A.
  • Dueling spacecraft look deep into Saturn and Jupiter January 17, 2019
    Voosen, P.